Nickel-catalyzed deaminative Sonogashira haɗakar gishiri na alkylpyridinium wanda NN2 pincer ligand ya kunna.

Alkynes suna yadu a cikin samfuran halitta, kwayoyin aiki masu aiki da ilimin halitta da kayan aikin kwayoyin halitta.A lokaci guda kuma, su ma mahimmancin tsaka-tsaki ne a cikin haɗaɗɗun kwayoyin halitta kuma suna iya ɗaukar halayen canjin sinadarai masu yawa.Sabili da haka, haɓaka hanyoyin gina alkynes mai sauƙi da inganci yana da gaggawa musamman kuma ana buƙata.Kodayake amsawar Sonogashira da aka catalyzed ta ƙarfe na tsaka-tsaki yana ɗaya daga cikin mafi inganci kuma hanyoyin da suka dace don haɗa aryl ko alkenyl maye gurbin alkynes, halayen haɗaɗɗen haɗakarwa waɗanda ba a kunna alkyl electrophiles ba saboda halayen gefe kamar kawar da bH.Har yanzu cike da ƙalubale da ƙarancin bincike, galibi iyakance ga rashin abokantaka na muhalli da tsadar alkanes halogenated.Sabili da haka, bincike da haɓaka halayen Sonogashira na sababbin, rahusa da sauƙin samuwa alkylation reagents zai kasance da mahimmanci duka biyu a cikin haɗin gwaje-gwaje da aikace-aikacen masana'antu.Ƙungiyar ta yi wayo ta ƙera da haɓaka sabon, sauƙin samuwa kuma barga mai nau'in nau'in NN2 pincer ligand, wanda a karon farko ya gane ingantaccen zaɓi na abubuwan alkylamine da ƙananan alkynes tare da kewayon nickel catalytic kafofin, arha kuma mai sauƙi. samu.An sami nasarar yin amfani da halayen haɗin gwiwar giciye zuwa ƙarshen deamination da gyare-gyaren alkynylation na samfuran halitta masu rikitarwa da ƙwayoyin ƙwayoyi, wanda ke nuna kyakkyawan aikin amsawa da daidaitawar ƙungiyar aiki, kuma yana ba da sabon abu don haɗakar mahimman alkynes masu maye gurbin alkynes.Kuma hanyoyi masu amfani.